ABSTRACT
To present the histopathological pattern of urinary bladder neoplasms using the WHO/ISUP classification system and relate it to the outcome. This study was conducted in the period from January 2004 through December 2005 at f three centres in Khartoum, Sudan. One hundred and six patients with urinary bladder neoplasms were included in the study. The commonest affected age group was 60-80 years with male to female ratio 4.6:1. Urothelial neoplasms were found in 72 [67.9%], Squamous cell carcinoma [SCC] in 26 [24.5%], Urothelial neoplasms with Squamous differentiation in 3 [2.8%], and other types in 5 [4.7%] of the patients. There were 43.4% of the urothelial neoplasms graded as papillary carcinoma of high grade, 52.6% papillary carcinoma of low grade, 1.3% papillary neoplasm of low malignant potential, 1.3% papilloma, and 1.3% was graded as flat neoplasm. Of the SCCs, twelve [42.9%] were poorly differentiated SCCs, nine [32.1%] moderately differentiated, and seven [25%] cases were well differentiated SCCs. Follow-up information was available in 32 patients. At last follow-up, fifteen [46.9%] patients were dead of the disease, twelve [35.5%] were alive with no evidence of disease, four [12.5%] were alive with disease, and one [3.1%] was alive and terminally ill. Histological grade [P: 0.006], and muscle invasion [P: 0.002] were significantly associated with survival. A subset of the cases could not be assessed for muscle invasion due to madequate sampling; we thus recommend proper trans-urethral bladder biopsy [TUEP] sampling